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82 , 83 , 84 , 85 In a study by Heintze, smokers had a significantly higher number of lactobacilli and Streptococcus mutans, considered major cariogenic bacteria

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Conclusion Overall, the study's findings demonstrated significant positive genetic causality between both smoking and coffee consumption and arthritis (both OA and RA), while the evidence for a genetic causal relationship between alcohol intake and arthritis was insufficient